CAS 7689-03-4 (+)-Camptothecin | Products & Prices & Suppliers

(+)-Camptothecin, with the chemical formula C20H16N2O4, has the CAS number 7689-03-4. It appears as a yellow crystalline powder with no distinct odor. The basic structure of (+)-Camptothecin consists of a pentacyclic ring system with a lactone moiety. This compound is sparingly soluble in water, but it is soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO). (+)-Camptothecin is known to be a potent cytotoxic agent and has shown promising anticancer activity in various studies. However, it is important to note that (+)-Camptothecin is also known to be unstable and undergoes hydrolysis in aqueous solutions.

Applicable Fields

Anticancer Agent: (+)-Camptothecin is primarily used as an anticancer agent. Its mechanism of action involves the inhibition of topoisomerase I, an enzyme involved in DNA replication and repair. By inhibiting topoisomerase I, (+)-Camptothecin prevents the resealing of DNA strands, leading to DNA damage and ultimately cell death. This mechanism has been exploited for the development of various anticancer drugs derived from (+)-Camptothecin, such as irinotecan and topotecan.

Storage

Conditions: Store in a cool and dry place, away from direct sunlight.