Cardiovascular Agents

Cardiovascular drug APIs (active pharmaceutical ingredients) are the chemical compounds that are responsible for the therapeutic effects of cardiovascular medications. These APIs are the key ingredients in medications used to treat a wide range of cardiovascular conditions, including hypertension, angina, heart failure, arrhythmias, and hyperlipidemia.
Some of the most commonly used cardiovascular drug APIs include:
Amlodipine: Amlodipine is a calcium channel blocker that is used to lower blood pressure and treat angina.
Atorvastatin: Atorvastatin is a statin medication that is used to lower LDL cholesterol levels and reduce the risk of heart disease.
Lisinopril: Lisinopril is an ACE inhibitor that is used to lower blood pressure and reduce the risk of heart attack and stroke.
Metoprolol: Metoprolol is a beta blocker that is used to lower blood pressure and reduce the risk of heart attack and stroke.
Warfarin: Warfarin is an anticoagulant that is used to prevent blood clots from forming and reduce the risk of stroke.
Digoxin: Digoxin is a cardiac glycoside that is used to improve the strength and efficiency of the heart's contractions, which can help to manage heart failure.
Diltiazem: Diltiazem is a calcium channel blocker that is used to treat hypertension and angina.
The development of cardiovascular drug APIs is a complex process that involves extensive research and testing to ensure their safety and efficacy. Once an API has been developed and tested, it can be used to manufacture a range of cardiovascular medications that are prescribed to millions of patients worldwide.
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Cardiovascular Agents X

calcium;(3R,5R)-7-[2-(4-fluorophenyl)-4-(C-oxido-N-phenylcarbonimidoyl)-3-phenyl-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate;(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid

Calcium is a chemical element with the symbol Ca and atomic number 20. It is a soft, silvery-white alkaline earth metal. Calcium is essential for living organisms, as it plays a vital role in many biological processes. It is commonly found in the form of calcium carbonate, which is a white powder wi..
CAS No: 134523-03-8
Molecular Weight: 1247.4496864
Molecular Formula:C₆₆H₇₂Ca₂F₂N₄O₁₃

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Telmisartan

White or off-white crystalline powder, odorless and tasteless. Soluble in chloroform, slightly soluble in methanol, very slightly soluble in acetone, practically insoluble in water. Slightly soluble in 0.1mol/L hydrochloric acid, soluble in 0.1mol/L sodium hydroxide.Absorption coefficient（E1％1cm）..
CAS No: 144701-48-4
Molecular Weight: 514.629
Molecular Formula:C₃₃H₃₀N₄O₂
Density:1.24
Boiling Point:771.9°Cat760mmHg
Flash Point:420.6°C

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Irbesartan

Crystalline SolidChEBI: A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.Avapro was launched in Germany, the UK and the US for hypertension. Itcan be prepared in six steps starting with cyclopentanone or in three steps from 1-aminocycl..
CAS No: 138402-11-6
Molecular Weight: 428.52942
Molecular Formula:C₂₅H₂₈N₆O
Density:1.3
Boiling Point:648.6 °C at 760 mmHg
Flash Point:346 °C

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D-Ribose

D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-depe..
CAS No: 50-69-1
Molecular Weight: 150.13
Molecular Formula:C₅H₁₀O₅
Density:1.681
Boiling Point:375.4 °C at 760 mmHg
Flash Point:180.8 °C

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Lovastatin

Lovastatin, with the chemical formula C24H36O5, has the CAS number 75330-75-5. It is a white to off-white crystalline powder with no distinct odor. Lovastatin is a naturally occurring statin that is derived from a fermentation product of Aspergillus terreus. Its basic structure consists of a lactone..
CAS No: 75330-75-5
Molecular Weight: 404.547
Molecular Formula:C₂₄H₃₆O₅
Density:1.12
Boiling Point:559.2 oC at 760 mmHg
Flash Point:185.3 oC

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Vinpocetine

Vinpocetine(Cavinton; Ethyl apovincaminate) is a selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels.IC50 value:Target: PDE1; Na+ channel Vinpocetine is an alkaloid. It has a role as a geroprotector.|Vinpocetine has been investigated for the treatment of Epilepsy.
CAS No: 42971-09-5
Molecular Weight: 350.45400
Molecular Formula:C₂₂H₂₆N₂O₂
Density:1.28 g/cm3
Boiling Point:419.5ºC at 760 mmHg
Flash Point:207.5ºC

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Enalapril maleate

Enalapril maleate, with the chemical formula C20H28N2O5.C4H4O4, has the CAS number 76095-16-4. It appears as a white to off-white, crystalline powder with a slight characteristic odor. The basic structure of enalapril maleate consists of a carboxyl group, an ethyl ester group, and a tetrahydrofuran ..
CAS No: 76095-16-4
Molecular Weight: 492.525
Molecular Formula:C₂₄H₃₂N₂O₉
Boiling Point:0°C
Flash Point:765.3 °C at 760 mmHg

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Clopidogrel hydrogen sulfate

Clopidogrel hydrogen sulfate is a chemical compound with the CAS number 135046-48-9. It is a hydrogen sulfate salt of clopidogrel, which is a medication used to prevent blood clots. Clopidogrel hydrogen sulfate appears as a white to off-white powder. It does not have a distinct odor. The molecular f..
CAS No: 135046-48-9
Molecular Weight: 419.9
Molecular Formula:C₁₆H₁₆ClNO₂S.H₂O₄S

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Quercetin

It is yellow needle-like crystalline powder. It has good thermal stability with the decomposition temperature being 314 °C. It can improve the light-tolerance property of food pigment for preventing the change of the flavor of food. Its color will change in case of metal ion. It is slightly soluble ..
CAS No: 117-39-5
Molecular Weight: 302.2357
Molecular Formula:C₁₅H₁₀O₇
Density:1.799
Boiling Point:642.4oCat 760 mmHg
Flash Point:248.1oC

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Carvedilol

Carvedilol(BM14190) is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation.IC50 Value: 3.8 μM ( inhibition of LDL oxidation)Target: beta Adrenergic ReceptorCarvedilol is a nonselective-blocking agent and is used in the treatment of hypertension and a..
CAS No: 72956-09-3
Molecular Weight: 406.48
Molecular Formula:C₂₄H₂₆N₂O₄
Density:1.25
Boiling Point:655.2 °C at 760 mmHg
Flash Point:350.1 °C

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Amlodipine

Amlodipine is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data sug..
CAS No: 88150-42-9
Molecular Weight: 408.8759
Molecular Formula:C₂₀H₂₅ClN₂O₅
Density:1.227
Boiling Point:527.2 °C at 760 mmHg
Flash Point:527.2 °C at 760 mmHg

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beta-Sitosterol

Beta-Sitosterol weakly inhibits porcine pancreatic lipase (PPL) activity. Sitosterol is an important compound extracted from the leaves of Aloe vera. Solid Sitosterol is a member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3. It has a role as ..
CAS No: 83-46-5
Molecular Weight: 414.71
Molecular Formula:C₂₉H₅₀O
Density:0.9540 (rough estimate)
Boiling Point:473.52°C (rough estimate)
Flash Point:226.3°C

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Atenolol

Atenolol is a selective β1 receptor antagonist.Target: Adrenergic ReceptorAtenolol is a cardioselective beta-adrenergic blocker possessing properties and potency similar to propranolol, but without a negative inotropic effect [1, 2].
CAS No: 29122-68-7
Molecular Weight: 266.33608
Molecular Formula:C₁₄H₂₂N₂O₃
Density:1.125
Boiling Point:
Flash Point:261.1°C

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Cilostazol

Cilostazol(OPC 13013; OPC 21) is a potent inhibitor of PDE3A, the isoform of PDE 3 in the cardiovascular system (IC50=0.2 uM).IC50 Value: 0.2 uM [1]Target: PDE3Ain vitro: Cilostazol caused a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency. Furthe..
CAS No: 73963-72-1
Molecular Weight: 369.52
Molecular Formula:C₂₀H₂₇N₅O₂
Density:1.34
Boiling Point:664.7 °C at 760 mmHg
Flash Point:355.8 °C

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Ubidecarenone

Ubidecarenone, also known as Coenzyme Q10 or CoQ10, has the chemical formula C59H90O4 and the CAS number 303-98-0. It is a naturally occurring compound that appears as a yellow to orange crystalline powder. Ubidecarenone has no distinct odor. Its basic structure consists of a benzoquinone ring attac..
CAS No: 303-98-0
Molecular Weight: 863.3435
Molecular Formula:C₅₉H₉₀O₄
Density:0.97
Boiling Point:869 °C at 760mmHg
Flash Point:324.5 °C

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Theophylline

Theophylline (CAS 58-55-9) is a white crystalline powder that belongs to the class of xanthine alkaloids. It has a basic structure consisting of a xanthine ring with two methyl groups at positions 1 and 3. Theophylline is sparingly soluble in water, with a solubility of about 8.3 mg/mL at 25°C. It i..
CAS No: 58-55-9
Molecular Weight: 180.16400
Molecular Formula:C₇H₈N₄O₂
Density:1.465 g/cm3
Boiling Point:454.1ºC at 760 mmHg
Flash Point:11°C

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Bisoprolol fumarate

Bisoprolol fumarate is a chemical compound with the CAS number 104344-23-2. It is a white or almost white crystalline powder with a faint characteristic odor. The molecular formula of bisoprolol fumarate is C18H31N5O4. It is sparingly soluble in water, but soluble in methanol and ethanol. Safety inf..
CAS No: 104344-23-2
Molecular Weight: 441.52
Molecular Formula:C₂₂H₃₅NO₈
Density:1.033
Boiling Point:445 °C at 760 mmHg
Flash Point:222.9 °C

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Pitavastatin calcium

Pitavastatin calcium is a chemical compound with the CAS number 147526-32-7. It is a white to off-white crystalline powder with no specific odor. The molecular formula of pitavastatin calcium is C50H46CaF2N2O8S2. It is slightly soluble in water and freely soluble in methanol and ethanol. Safety info..
CAS No: 147526-32-7
Molecular Weight: 463.56
Molecular Formula:C₂₅H₂₆CaFNO₄
Boiling Point:692 °C at 760 mmHg
Flash Point:372.3 °C

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Eplerenone

White SolidEplerenone derives its antihypertensive effect by blocking the binding of aldosteroneat the mineralocorticoid receptor (MR). The drug, which was previously approvedonly for the oral treatment of hypertension, is now indicated to improve survival ofstable patients with left ventricular sys..
CAS No: 107724-20-9
Molecular Weight: 414.498
Molecular Formula:C₂₄H₃₀O₆
Density:1.31
Boiling Point:597.9°Cat760mmHg
Flash Point:259.5°C

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Candesartan

Crystalline SolidChEBI: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin eceptor antagonist used for the treatment of hypertension...
CAS No: 139481-59-7
Molecular Weight: 440.454
Molecular Formula:C₂₄H₂₀N₆O₃
Density:1.41
Boiling Point:754.8 °C at 760 mmHg
Flash Point:410.3 °C

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