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Sodium alginate
- CAS No.: 9005-38-3
- Molecular Weight：398.31668
- Modify Date.: 2022-11-02 06:52
- Introduction: Sodium alginate, with the chemical formula C6H9NaO7 and CAS registry number 9005-38-3, is a compound derived from brown seaweed. This water-soluble polysaccharide is commonly used as a thickening, stabilizing, and gelling agent in various industries, including food, pharmaceuticals, and cosmetics. Sodium alginate plays a significant role in food applications, where it is utilized to improve texture, enhance mouthfeel, and create unique culinary presentations. In brewing industry as auxiliary fining agent, foam stabilizer. Its ability to form gels in the presence of calcium ions makes it particularly useful in the production of gels, films, and beads for controlled drug delivery systems in pharmaceutical formulations. Additionally, sodium alginate finds application in tissue engineering, textile printing, and wound dressings due to its biocompatibility and biodegradability.
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1. Names and Identifiers
- 1.1 Name
- Sodium alginate
- 1.2 Synonyms
6-[(2-carboxy-4,5-dihydroxy-6-methoxy-3-oxanyl)oxy]-4,5-dihydroxy-3-methoxy-2-oxanecarboxylic acid Alginate Sodium Alginic Acid Sodium Salt, Technical Grade Alginicacidsodiumsalt,lowviscosity CuringBon EINECS 905-385-3 FEMA 2015 hzsn MFCD00081310
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- 1.3 CAS No.
- 9005-38-3
- 1.4 CID
- 5102882
- 1.5 EINECS(EC#)
- 618-415-6
- 1.6 Molecular Formula
- C6H9NaO7 (isomer)
- 1.7 Inchi
- InChI=1S/C6H10O7.Na/c7-1-2(8)4(5(10)11)13-6(12)3(1)9;/h1-4,6-9,12H,(H,10,11);/q;+1/p-1
- 1.8 InChIkey
- MSXHSNHNTORCAW-UHFFFAOYSA-M
- 1.9 Canonical Smiles
- C1(C(C(OC(C1O)O)C(=O)[O-])O)O.[Na+]
- 1.10 Isomers Smiles
- C1(C(C(OC(C1O)O)C(=O)[O-])O)O.[Na+]
2. Properties
- 2.1 Density
- 1.0 g/cm3(Temp: 25 °C)
- 2.1 Melting point
- > 300 C
- 2.1 Boiling point
- 495.2 °C at 760 mmHg
- 2.1 Flash Point
- 495.2 °C at 760 mmHg
- 2.1 Precise Quality
- 216.02500
- 2.1 PSA
- 130.28000
- 2.1 logP
- -4.46380
- 2.1 Appearance
- white to light yellow granules or powder
- 2.2 Storage
- Hygroscopic. Ambient temperatures.
- 2.3 Chemical Properties
- Colorless or slightly yellow solid occur-ring in filamentous, granular, and powdered forms.Forms a viscous colloidal solution with water;insoluble in alcohol, ether, and chloroform. Com-bustible.
- 2.4 Color/Form
- Cream-colored powder
Filamentous or granular solid or powder
- 2.5 PH
- 6.0-8.0 (10mg/mL in H2O)
- 2.6 Water Solubility
- soluble
- 2.7 Stability
- Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
- 2.8 StorageTemp
- Store at RT.
3. Use and Manufacturing
- 3.1 History
- Sodium alginate is a natural polysaccharide product that was first described in a patent application by the British chemist Edward C C Stanford in 1881. To this day brown algae are still the main source used to extract sodium alginate from. This group includes many of the seaweeds, like kelps, found in chilly northern seas. In addition to the food industry, the gelling properties of sodium alginate have been used in medical, dental and cosmetic applications for years.
- 3.2 Produe Method
- Alginic acid is extracted from brown seaweed and is neutralizedwith sodium bicarbonate to form sodium alginate.
- 3.3 Usage
-
In brewing industry as auxiliary fining agent, foam stabilizer.
4. Safety and Handling
- 4.1 Hazard Codes
- Xi
- 4.1 Risk Statements
- 36/37/38
- 4.1 Safety Statements
- S24/25
- 4.1 Exposure Standards and Regulations
- Substance added directly to human food affirmed as generally recognized as safe (GRAS).
Sodium alginate used as a stabilizer in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
- 4.2 DisposalMethods
- SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
- 4.3 RIDADR
- 25kgs
- 4.3 FirePotential
- COMBUSTIBLE
- 4.4 Safety Profile
- Poison by intravenous and intraperitoneal routes. When heated to decomposition it emits toxic fumes of Na2O
- 4.5 Formulations/Preparations
- It consists chiefly of sodium salt of alginic acid, polyuronic acid composed of beta D-mannuronic acid residues linked so that carboxyl group of each unit is free while aldehyde group is shielded by glycosidic linkage.
All derivatives of alginic acid ... designated by the generic term algin. ... Most commonly used algin compound is sodium alginate ... often used interchangeably.
Trade names include Alginate, SFC; Cecalgum, Sanofi; Dialgin, Diamalt; Keltex, Kelco; Lamitex, Protan; Manutex, Kelco.
Dental alginates are powder mixtures with the following composition: sodium alginate (10 ? 20 wt %), calcium sulfate (10 wt %), trisodium phosphate (1 ? 4 wt %), diatomite (70 ? 80 wt %), color and flavor (1 ? 2 wt %).
- 4.6 Incompatibilities
- Sodium alginate is incompatible with acridine derivatives, crystalviolet, phenylmercuric acetate and nitrate, calcium salts, heavymetals, and ethanol in concentrations greater than 5%. Lowconcentrations of electrolytes cause an increase in viscosity but highelectrolyte concentrations cause salting-out of sodium alginate;salting-out occurs if more than 4% of sodium chloride is present.
- 4.7 WGK Germany
- 1
- 4.7 RTECS
- AZ5820000
- 4.7 Report
-
Reported in EPA TSCA Inventory.
?
- 4.8 Safety
-
Safety Description?of Sodium alginate (CAS NO.9005-38-3): 24/25?
S24/25: Avoid contact with skin and eyes.
Poison by intravenous and intraperitoneal routes. When heated to decomposition it emits toxic fumes of Na2O.
- 4.9 Specification
-
solid
Safety Statements:24/25-36-26
24/25:Avoid contact with skin and eyes
36:Wear suitable protective clothing
26:In case of contact with eyes, rinse immediately with plenty
of water and seek medical advice
- 4.10 Toxicity
-
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| cat |
LD50 |
intraperitoneal |
250mg/kg (250mg/kg) |
? |
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 381, 1974. |
| mouse |
LDLo |
intraperitoneal |
500mg/kg (500mg/kg) |
BLOOD: HEMORRHAGE |
Indian Journal of Physiology and Pharmacology. Vol. 12, Pg. 129, 1968. |
| rabbit |
LD50 |
intravenous |
100mg/kg (100mg/kg) |
? |
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 381, 1974. |
| rat |
LD |
intraperitoneal |
> 1gm/kg (1000mg/kg) |
? |
Indian Journal of Physiology and Pharmacology. Vol. 12, Pg. 129, 1968. |
| rat |
LD50 |
intravenous |
1gm/kg (1000mg/kg) |
? |
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 381, 1974. |
| rat |
LD50 |
oral |
> 5gm/kg (5000mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 42, 1982. |
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5. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
no data available
2.2 GHS label elements, including precautionary statements
| Pictogram(s) | no data available |
| Signal word | no data available |
| Hazard statement(s) | no data available |
| Precautionary statement(s) | |
| Prevention | no data available |
| Response | no data available |
| Storage | no data available |
| Disposal | no data available |
2.3 Other hazards which do not result in classification
no data available
7. Other Information
- 7.0 Usage
- A gelling polysaccharide extracted from giant brown seaweed, it is useful in viscosity studiesAlginic acid sodium salt is widely utilized in the food industry as flavorless gum which enhances viscosity and acts as an emulsifier. It finds application as a thickener for reactive dyestuffs which is used in textile screen printing and carpet jet-printing. It is used as indigestion tablets and for the preparation of dental impressions. As a polymer, it combines with chitosan to synthesize a biodegradable porous scaffold which is useful for tissue engineering applications. It acts as a food additive and is used in production of gel-like foods such as baking. It is also used for encapsulating agents of microparticles of beta-galactosidae and in the preparation of alginate hydrogels with tunable mechanical properties.
- 7.1 Usage
- A gelling polysaccharide extracted from giant brown seaweed, useful in viscosity studiesAlginic acid sodium salt is widely utilized in food industry as flavorless gum, which enhances viscosity and as an emulsifier. It finds application as thickener for reactive dyestuffs, which is used in textile screen printing and carpet jet-printing. It is used indigestion tablets and the preparation of dental impressions. As a polymer, it combines with chitosan to synthesize a biodegradable porous scaffold, which is useful for tissue engineering applications. It acts as a food additive and involved in the production of gel-like foods such as bakers. It is employed as thickener for reactive dyestuffs in textile screen-printing and carpet jet-printing. It is also used as encapsulating agents of microparticles of beta-galactosidae and in the preparation of alginate hydrogels with tunable mechanical properties.
- 7.2 Usage
- It is a hematologic agent, drug that acts on blood and blood-forming organs and those that affect the hemostatic system. sodium alginate has been used in warp sizing, packing and printing. In printing, it is an ideal kind of material with wide applications in the cotton, wool, silk and synthetic fiber. Sodium alginate is widely used in food industry such as it is the main material of seaweed, synthetic grape and synthetic cherry, it is taken as a stabilizer of ice cream and ice cream bar because of its dense organization and slow solution speed. It is also the main material of the dainty cold powder and jelly, As a stabilizer of cake (such as cookies, bread, fine dried noodle, chocolates) and a polish of bread, sodium alginate can keep the cookies sweet-smelling and avoid falling to pieces, and make the noodle smooth and reduce breaking ratio of noodle and fragmentation of bread. Sodium alginate is also a good thickener of jam, chili sauce, jelly, tomato ketchup, fishpaste, pudding and salad flavoring.
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8. Computational chemical data
- Molecular Weight: 398.31668g/mol
- Molecular Formula: C6H9NaO7
- Compound Is Canonicalized: True
- XLogP3-AA: null
- Exact Mass: 216.02459690
- Monoisotopic Mass: 216.02459690
- Complexity: 210
- Rotatable Bond Count: 1
- Hydrogen Bond Donor Count: 4
- Hydrogen Bond Acceptor Count: 7
- Topological Polar Surface Area: 130
- Heavy Atom Count: 14
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count: 5
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Isotope Atom Count: 0
- Covalently-Bonded Unit Count: 2
- CACTVS Substructure Key Fingerprint: AAADccBgOCAAAAAAAAAAAAAAAAAAAAAAAAAkAAAAAAAAAAAAAAAAGgAACAAACBSwgAMACAAABgAIAACQCAIAAAAAAAAAAAFAAAAREBYAAAQCQAAFIAAHAAHKbARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
9. Question & Answer
-
General Description Sodium alginate, a versatile polysaccharide, exhibits diverse physico-chemical, mechanical, and biological properties. Its molecular weight and pH influence viscosity, gel properti..
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Introduction: Sodium Alginate, as a multifunctional compound, has a wide range of applications. However, as its usage in the food industry gradually increased, people began to pay attention to the si..
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Introduction: Sodium Alginal is a natural linear polysaccharide, which is connected by β-D-manlactarin and alpha-L-ant Luoshionic acid alternately. It has many unique properties, so that it has a wi..
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Introduction: Sodium alginate and calcium lactate are two common food additives, which are widely used in the food industry. Sodium Alginate, as a stabilizer and thicker, is commonly used in foods su..
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