3D Mol Similar

Diosmin

: Iupac Name：5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one; CAS No.: 520-27-4; Molecular Weight：608.549; Modify Date.: 2024-02-16 16:15; Introduction:
Diosmin, with the chemical formula C28H32O15 and CAS registry number 520-27-4, is a compound known for its medicinal properties. It is a flavonoid glycoside found in various plants, particularly citrus fruits. Diosmin is commonly used as a dietary supplement and is known for its potential benefits in promoting blood circulation and reducing inflammation. It is often used in the treatment of venous disorders, such as chronic venous insufficiency and hemorrhoids. Diosmin has also been studied for its potential antioxidant and anticancer properties. Overall, Diosmin is a compound with diverse therapeutic applications and continues to be a subject of scientific research.
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1. Names and Identifiers

: 1.1 Name; Diosmin; 1.2 Synonyms; 3',5,7-trihydroxy-4'-methoxyflavone 7-rutinoside 3',5,7-Trihydroxy-4'-methoxyflavone-7-rutinoside 3',5-Dihydroxy-4'-methoxy-7-(6-O-α-L-rhamnopyranosyl-β-D-glucopyranosyloxy)flavone 3′,5,7-Trihydroxy-4′-methoxyflavone 7-O-rutinoside 3′,5-Dihydroxyl-4′-methoxylflavanone-7-O-α-L-rhamnosyl (1→6)-β-D-glucopyranoside 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-α-L-mannopyranosyl)-Β- D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)- 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-α-L-mannopyranosyl)-Β-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)- 4H-1-Benzopyran-4-one, 7-[[(5ξ)-6-O-[(5ξ)-6-deoxy-α-L-ribo-hexopyranosyl]-β-D-arabino-hexopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)- 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxyhexopyranosyl)hexopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)- 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-altropyranosyl)-α-L-gulopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)- 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)- 5-Hydroxy-2-(3-hydroxy-4-méthoxyphényl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}méthyl)tétrahydro-2H-pyran-2-yl]oxy}-4H-chromén-4-one 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-chromen-7-yl (5ξ)-6-O-[(5ξ)-6-deoxy-α-L-ribo-hexopyranosyl]-β-D-arabino-hexopyranoside 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-chromen-7-yl 6-O-(6-deoxyhexopyranosyl)hexopyranoside 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-chromen-7-yl 6-O-(6-deoxy-α-L-altropyranosyl)-α-L-gulopyranoside 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-chromen-7-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-Β-D-glucopyranoside 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-chromen-7-yl-6-O-(6-deoxy-α-L-mannopyranosyl)-Β-D-glucopyranoside 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(O6-a-L-rhamnopyranosyl-b-D-glucopyranosyloxy)chromen-4-one 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-on 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-one 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{3,4,5-trihydroxy-6-[(3,4,5-trihydro xy-6-methyl(2H-3,4,5,6-tetrahydropyran-2-yloxy))methyl](2H-3,4,5,6-tetrahydrop yran-2-yloxy)}chromen-4-one 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-methyl(2H-3,4,5,6-tetrahydropyran-2-yloxy))methyl](2H-3,4,5,6-tetrahydropyran-2-yloxy)}chromen-4-one 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-b-rutinosyloxy-4H-chromen-4-one 7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one 7-[[6-O-6-Deoxy-a-L-mannopyranosyl-b-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one Barosmin BAROSMIN hplc Buchu resin DIOSIMIN Diosmetin 7-b-Rutinoside Diosmetin 7-O-rhamnosyl(1→6)-glucoside Diosmetin 7-O-rutinoside Diosmetin 7-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside Diosmetin 7-rutinoside Diosmetin 7-β-rutinoside DIOSMETIN-7-O-RUTINOSIDE diosmetin-7-rhamnoglucoside DIOSMETIN-7-RUTINOSIDE Diosmil Diosmine Diosven Dioven Diovenor EINECS 208-289-7 Flebodia Flebosmil Flebosten Hemerven Insuven Litosmil MFCD00009772 Phlebodia Tovene UNII-7QM776WJ5N Varinon Ven-Detrex Venex 500 Venosmine Veno-V; View all

1.3 CAS No.: 520-27-4

1.4 CID: 5281613

1.5 EINECS(EC#): 208-289-7

1.6 Molecular Formula: C28H32O15 (isomer)

1.7 Inchi: InChI=1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

1.8 InChIkey: GZSOSUNBTXMUFQ-YFAPSIMESA-N

1.9 Canonical Smiles: CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

1.10 Isomers Smiles: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

2. Properties

2.1 Density: 1.68

2.1 Melting point: 277-278 °C

2.1 Boiling point: 926.8 °C at 760 mmHg

2.1 Refractive index: 1.711

2.1 Flash Point: 305.2 °C

2.1 Precise Quality: 608.17400

2.1 PSA: 238.20000

2.1 logP: -1.08970

2.1 Λmax: 345nm(EtOH)(lit.)

2.2 Appearance: Greyish-yellow or light yellow hygroscopic powder

2.3 Storage: Keep Cold.

2.4 Chemical Properties: Brown powder

2.5 Color/Form: Yellow powder

2.6 pKa: 6.10±0.40(Predicted)

2.7 Water Solubility: Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides.

2.8 StorageTemp: Sealed in dry,2-8°C

3. Use and Manufacturing

3.1 Definition: ChEBI: A disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.

3.2 GHS Classification: Signal: Warning
GHS Hazard Statements
Aggregated GHS information provided by 69 companies from 2 notifications to the ECHA C&L Inventory.

Reported as not meeting GHS hazard criteria by 64 of 69 companies. For more detailed information, please visit ECHA C&L website

Of the 1 notification(s) provided by 5 of 69 companies with hazard statement code(s):

H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P201, P202, P281, P308+P313, P405, and P501; View all

3.3 Usage: Used in food, medicine, health products, etcAction mechanism:1.Enhance the vein tension, even not exceptional under high temperature condition. It has a stronger effect causing the constriction of vein than other drugs such as rutin, still can enhance the tension of the vein when the body was acidosis. Diosmin has specific affinity for vein without affecting the arterial system. 2. Improve microcirculation. Diosmin can obviously reduce the white blood cells and vascular endothelial cell adhesion, migration, disintegrating the release of inflammatory substances, such as histamine, slow excitation peptide, complement, leukotriene, prostaglandins, and too many free radicals, reducing the permeability of capillaries and enhance its tension. Diosmin can lower blood viscosity, enhance the function of red blood cell velocity, thus reduce the microcirculation clogged. 3. Promote lymphatic circumfluence. Diosmin can increase the speed of lymphatic drainage.

4. Safety and Handling

4.1 Hazard Codes: Xi

4.1 Risk Statements: R36/37/38

4.1 Safety Statements: S26;S36

4.1 RIDADR: NONH for all modes of transport

4.1 WGK Germany: 3

4.1 Report: ?Diosmin (CAS NO.520-27-4) is reported in EPA TSCA Inventory.

4.2 Safety: Hazard Codes: Xi
WGK Germany: 3
Risk Statements:?36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:?26-36-36/37
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.?
S36/37:Wear suitable protective clothing and gloves.

4.3 Specification: Mechanisms of? Diosmin (CAS NO.520-27-4):
1、Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries.
2、Diosmin prolongs the vasoconstrictor effect of noradrenaline on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis.
3、Furthermore, diosmin with hesperidine decreases the diameter of lymphatic capillaries and the intralymphatic pressure
4、At the microcirculation level, diosmin reduces capillary hyperpermeability and increases capillary resistance by protecting the microcirculation from damaging processes.

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s)	No symbol.
Signal word	No signal word.
Hazard statement(s)	none
Precautionary statement(s)
Prevention	none
Response	none
Storage	none
Disposal	none

2.3 Other hazards which do not result in classification

none

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6. NMR Spectrum

13C NMR : Predict

1H NMR : Predict

Predict 1H proton NMR

IR : KBr disc

IR : nujol mull

7. Synthesis Route

520-27-4Total: 2 Synthesis Route

520-26-3 453 Suppliers

520-27-4 408 Suppliers

Literatures:
Archiv der Pharmazie, , vol. 316, # 3 p. 219 - 222
Yield: ~89%

69081-76-1

520-27-4 408 Suppliers

Literatures:
Chemische Berichte, , vol. 76, p. 452,457
Yield: null

8. Precursor and Product

precursor:

520-26-3

69081-76-1

product :

5128-44-9

480-44-4

480-36-4

9. Other Information

9.0 Usage: Diosmin exhibits anti-proliferative and anti-inflammatory. It is used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD).

9.1 Merck: 14,3297

9.2 Pharmacological Effects: Diosmin is also called Alvenor. It is a kind of drug for the treatment of hemorrhoid symptoms related to acute episodes, can also be used in the treatment of symptoms associated with venous lymphatic insufficiency (leg heavy, pain, morning acid swells discomfort).
The effects of diosmin are as below:
1, Has specific affinity to the venous system, enhance the tension system without affecting the artery of vein;
2, To the microcirculation system, decrease the blood viscosity, improve the velocity of reducing silt up;
3, Contract the lymphatic system, which can enhance lymphatic and lymph drainage speed, speed up the return relieve edema.
4, Commercially available diosmin uses micronization technology, increase the contact area after using medicine, absorb more and higher bioavailability. Suitable for all kinds of hemorrhoids and acute hemorrhoids, also can be used for the treatment of chronic venous insufficiency, such as varicose veins, leg ulcers, etc.
This information is edited by Xiao Nan.; View all

9.3 Description: Diosmin was separated from the root of Scrophularia nodosa L. in 1925. The root of Scrophularia nodosa L. has the function of nourishing, reducing fever, relieving internal heat, and detoxicating. It was firstly recorded in the Shen Nong’s Classic of Materia Medica, as a class of middle-grade drug and is currently recorded in the Ch.P 2015, Volume I. The natural resource was abundant in China, mainly provided from Zhejiang, Sichuan, Hubei, Anhui, and Jiangsu provinces. In the clinical practice, Scrophularia nodosa L. was employed to eliminate pathogenic heat from the blood. In the clinical indication, diosmin was mainly applied to treat fever, polydipsia, maculitis, gingivitis, amygdalitis, laryngopharyngitis, acute lymphadenitis, etc. It also has the biological function of antiplatelet aggregation and antitumor. The chemical components include iridoids, phenylpropanoid glycoside, flavonoids, and fatty acids.

9.4 Chemical Properties: Diosmin is a natural flavonoid mainly present in the peel of some citrus fruits, such as oranges and lemons. Flavonoids are anti-inflammatory plant compounds that protect your body from free radicals and other unstable molecules. The most prevalent uses for Diosmin include hemorrhoids and leg sores caused by poor blood flow. Diosmin was first found in 1925 in the wort plant and has since been used as a natural treatment for hemorrhoids, varicose veins, venous insufficiency, leg ulcers, and other circulatory issues.

9.5 Physical properties: Appearance: Grayish yellow or light yellow hygroscopic powder. Solubility: Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides. Melting point: 277–278°C.

9.6 Originator: Diosmil,Bellon,France,1971

9.7 History: Diosmin was firstly introduced as a medicine in 1969. It was launched in France in 1987 with the product name “Alvenor.” As the protecting agent for blood vessel and therapeutic agent for chronic venous disease, diosmin has been used for over 30?years in Europe
Diosmin is a typical flavonoid. It could be prepared from natural resources or semisynthesized from the natural product hesperidin by dehydrogenation reaction.

9.8 Uses: Diosmin is an agonist of the aryl hydrocarbon receptor (AhR) and exhibits anti-proliferative and anti-inflammatory. It is used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD). Diosmin also reduces capillary hyperpermeability and expression of endothelial adhesion molecules (ICAM1, VCAM1). It effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells.

9.9 Application: Diosmin is a naturally occurring flavonic glycoside isolated from various plants. Diosmin is a capillary protectant and It is used for the improvement of capillary fragility or venous insufficiency, including chronic venous insufficiency (CVI) and hemorrhoids. Diosmin is widely available over-the-counter and demonstrates a favourable a favorable safety profile.

9.10 Indications: The clinical indications of diosmin are those symptoms related to venous-lymphatic dysfunction such as leg heaviness, pains, soreness, and swelling in the morning. Besides, the symptoms related to acute hemorrhoids could also be treated with diosmin.

9.11 Definition: ChEBI: Diosmin is a disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and an anti-inflammatory agent. It is a glycosyloxyflavone, a rutinoside, a disaccharide derivative, a monomethoxyflavone and a dihydroxyflavanone. It derives from a diosmetin.

9.12 Manufacturing Process: A mixture of 72 g hesperidin, 288 ml acetic anhydride and 300 ml glacial acetic acid were boiled in reflux with 15 ml pyridine as the catalyst for 144 hours until during the control of the reaction the band disappeared at a wave length between 264 to 280 nm, and a new maximum appeared at 330 nm. Thereafter in a rotation evaporator the reaction mixture was concentrated by evaporation under vacuum conditions.
The residue was absorbed in 1,200 ml ethyl acetate, admixed with 20 ml ethanol and boiled for one hour under reflux action. The solution was filtered and compressed to dryness. The residue was dried in a vacuum drying cabinet. The yield amounted to 107.5 g.
35.8 g thereof were then dissolved in 280 ml glacial acetic acid and
ominated with a solution of 6.05 g
omine in 30 ml glacial acetic acid. Thereafter the mixture compressed to dryness by means of the rotation evaporator, there being obtained a residue of 41.8 g. Such was dissolved in 150 ml methanol, admixed with a solution of 36 g sodium hydroxide in 180 ml water and stirred for one hour at 50°C.
The diosmin was precipitated out by adding 120 ml glacial acetic acid and stirring at 70°C for 30 minutes. The precipitate was filtrated in a suction filter or strainer, washed with methanol, water and again methanol and dried at 60°C in the drying cabinet. Raw yield: 17.0 g corresponding to 71% yield.
omine content 0.51%.
10 g of the thus-obtained diosmin was dissolved in a solution of 24 g sodium hydroxide in 120 ml water, admixed with 100 ml methanol and 100 ml pyridine and stirred for one hour at 50°C. The diosmin was precipitated by the addition of 100 ml glacial acetic acid and stirred for 30 minutes at 70°C, filtered and washed with methanol and water and again methanol.
After drying at 60°C there was obtained a pure yield of 9.2 g diosmin (65% based upon the employed hesperidin) having a
omine content of 0.07%.; View all

9.13 Therapeutic Function: Bioflavonoid

9.14 Pharmacology: Diosmin is a micronized, purified, flavonoid-structure drug. It is helpful for lymphatic return and stimulating microcirculation, treating hemorrhoids and venous dysfunction by increasing the venous tension.
1. Increasing the venous tension. Diosmin could strengthen the tensile force of the venous wall even under high temperature. Diosmin’s action in venous constriction is stronger than other drugs like rutin. Even under the acidic toxicity in the body, it could still raise the venous tension. Diosmin has special affinity to the venous other than the arterial system.
2. Improving the microcirculation. Diosmin could effectively reduce adhesion and migration of leukocyte and vascular endothelial cells. It could also release inflammatory substances such as histamine, bradykinin, alexin, leukotriene, prostaglandin, and surplus free radicals. Hence, the penetration of capillary blood vessel was reduced, and the tension was enhanced. Besides, diosmin could decrease blood viscosity, accelerate erythrocyte flow rate, and finally reduce the chances of microcirculatory stasis
3. Stimulating the lymphatic return. Diosmin could effectively increase the speed of lymphatic drainage and the lymphatic contraction, accelerating the circumfluence of interstitial fluid, improving lymphatic return, and relieving edema.; View all

9.15 Clinical Use: Diosmin was mainly used to treat diseases like chronic venous dysfunction, haemorrhoids, lymphedema, phlebeurysm, etc.

9.16 Side effects: Diosmin can cause some side effects such as nausea, stomach pain, diarrhea, insomnia, dizziness, headache, drowsiness, skin redness and hives, muscle pain, blood problems, and altered heart rate.
There may be a few of minor gastrointestinal reactions and adverse reactions such as plant nerve function disorder, but generally mild and don't have to stop the drug.
Pregnant women and nursing mothers with hemorrhoids are safe to use this product.

9.17 Mode of action: 1. Enhance the vein tension, even not exceptional under high temperature condition. It has a stronger effect causing the constriction of vein than other drugs such as rutin, still can enhance the tension of the vein when the body was acidosis. Diosmin has specific affinity for vein without affecting the arterial system.
2. Improve microcirculation. Diosmin can obviously reduce the white blood cells and vascular endothelial cell adhesion, migration, disintegrating the release of inflammatory substances, such as histamine, slow excitation peptide, complement, leukotriene, prostaglandins, and too many free radicals, reducing the permeability of capillaries and enhance its tension. Diosmin can lower blood viscosity, enhance the function of red blood cell velocity, thus reduce the microcirculation clogged.
3. Promote lymphatic circumfluence. Diosmin can increase the speed of lymphatic drainage.

10. Computational chemical data

Molecular Weight: 608.549g/mol
Molecular Formula: C₂₈H₃₂O₁₅
Compound Is Canonicalized: True
XLogP3-AA: -0.8
Exact Mass: 608.17412031
Monoisotopic Mass: 608.17412031
Complexity: 995
Rotatable Bond Count: 7
Hydrogen Bond Donor Count: 8
Hydrogen Bond Acceptor Count: 15
Topological Polar Surface Area: 234
Heavy Atom Count: 43
Defined Atom Stereocenter Count: 10
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1
CACTVS Substructure Key Fingerprint: AAADcfB4PAAAAAAAAAAAAAAAAAAAAAAAAAA0aIECAAAAAACBQAAAGgAACAAADBSwmAMyDoAABgCIAqBSAAACCAAkIAAIiAEGiMgdNzaGNRqieWOl4BUPuQfI7LzOIAABCAAIQABAAAIQABCAAAAAAAAAAA==

11. Question & Answer

What is Daflon 500 mg and how does it compare to nonmicronized diosmin in treating chronic venous insufficiency? Jun 17 2024
Daflon 500 mg is a micronized purified flavonoid fraction containing 450 mg of diosmin and 50 mg of hesperidin per tablet, designed for better gastrointestinal absorption. Diosmin, extracted from pla..
What are the applications and market performance of Diosmin? Oct 22 2023
Diosmin is an important pharmaceutical ingredient widely used in the medical field. So, in which areas does Diosmin have applications and how does it perform in the market? This article will introduc..
Can Diosmin Powder Improve Venous Diseases? Mar 10 2023
The medicinal value of Diosmin powder is relatively high. This product itself is a therapeutic drug that is effective in improving acute symptoms of hemorrhoids or other conditions and can also be use..
What should we pay attention to when using Diosmin? Oct 28 2022
The medicinal value that Diosmin can exert is still very high. When using it, we must carefully read the product instructions and use it correctly. This product has very good effects on protecting blo..

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13. Realated Product Infomation

1431536-92-3 6-Iodo DiosMin

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