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Use 2-methyl-5-bromobenzoic acid is a kind of pharmaceutical intermediate, and it has been reported that it can be used in the preparation of caraglizin. The intermediate 2-methyl-5-bromobenzoic acid was synthesized by adding liquid bromine with molar ratio of 1.05 under the action of metal reagent Fe powder and superacid catalyst Chemicalbook trifluoromethanesulfonic acid, and the solvent liquid bromine was pretreated with absolute anhydrous molecular zeolite. The yield was above 85%.
Use 2-methyl-5-bromobenzoic acid is a kind of pharmaceutical intermediate, and it has been reported that it can be used in the preparation of caraglizin. The intermediate 2-methyl-5-bromobenzoic acid was synthesized by adding liquid bromine with molar ratio of 1.05 under the action of metal reagent Fe powder and superacid catalyst Chemicalbook trifluoromethanesulfonic acid, and the solvent liquid bromine was pretreated with absolute anhydrous molecular zeolite. The yield was above 85%.
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