1.Identification
1.1 GHS Product identifier
| Product name | acetylsalicylic acid |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | 2-Acetoxybenzoic acid,O-Acetylsalicylic acid,ASA |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | For industry use only. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | WWW.GuideChem.COM |
|---|---|
| Address | 8F, Block C, No.3 Building, Zijin Plaza, No.701, Gudun Road, Hangzhou, Zhejiang 310030, China |
| Telephone | +86-571-89739798 |
| Fax | 86(21)54365166 |
1.5 Emergency phone number
| Emergency phone number | +86-571-89739798 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 4
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |  |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H302 Harmful if swallowed |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. |
| Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell. P330 Rinse mouth. |
| Storage | none |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| acetylsalicylic acid | acetylsalicylic acid | 50-78-2 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Refer for medical attention.
In case of skin contact
Rinse skin with plenty of water or shower. Refer for medical attention .
In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed
Rinse mouth. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, upper respiratory system; increased blood clotting time; nausea, vomiting; liver, kidney injury Target Organs: (NIOSH, 2016)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
The use of paralytic agents and difficulty in achieving the very high minute volumes needed tend to induce respiratory acidosis in the patient. Aspirin (pKa = 3.5) becomes non-ionized at an acidic pH and crosses the blood-brain barrier more readily, increasing its toxic central effects. It is the tissue rather than plasma levels that are dangerous to the patient. Noncardiogenic pulmonary edema interferes with oxygenation of the patient and high concentrations of inspired oxygen may be required.
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.
5.2 Specific hazards arising from the chemical
This chemical is combustible.
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Well closed.Chewable aspirin tablets containing 81 mg of the drug should be stored in child-resistant containers holding not more than 36 tablets each in order to limit the potential toxicity associated with accidental ingestion in children. Aspirin suppositories should be stored at 2-15\u00b0C.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 mg/cu m.
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
| Physical state | white to off-white crystalline powder |
|---|---|
| Colour | Monoclinic tablets or needle-like crystals |
| Odour | Odorless, but in moist air it is gradually hydrolyzed and acquires odor of acetic acid |
| Melting point/ freezing point | 304\u00b0C(lit.) |
| Boiling point or initial boiling point and boiling range | 120\u00b0C |
| Flammability | Combustible Powder; explosion hazard if dispersed in air.Combustible. |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 250\u00b0C |
| Auto-ignition temperature | no data available |
| Decomposition temperature | 140\u00b0C |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | In water:3.3 g/L (20 \u00baC) |
| Partition coefficient n-octanol/water (log value) | no data available |
| Vapour pressure | 0 mm Hg (approx) (NIOSH, 2016) |
| Density and/or relative density | 1.35 |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
STABLE IN DRY AIR; IN MOIST AIR IT IS GRADUALLY HYDROLYZED INTO SALICYLIC AND ACETIC ACIDS
10.3 Possibility of hazardous reactions
SLIGHT WHEN EXPOSED TO HEAT OR FLAMEDust explosion possible if in powder or granular form, mixed with air.The active ingredient in common aspirin. Incompatible with oxidizers and strong acids. Also incompatible with strong bases. May react with water or nucleophiles (e.g. amines and hydroxy groups). May also react with acetanilide, amidopyrine, phenazone, hexamine, iron salts, phenobarbitone sodium, quinine salts, potassium and sodium iodides, alkali hydroxides, carbonates, stearates and paracetanol.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Solutions of alkali hydroxides or carbonates, strong oxidizers, moisture [Note: Slowly hydrolyzes in moist air to salicyclic & acetic acids].
10.6 Hazardous decomposition products
When heated to decomposition it emits acrid smoke and fumes.
11.Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 1500 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water flea, <24 hr neonate); Conditions: freshwater, static, 21\u00b0C, pH 7.6; Concentration: 8.15 mM for 24 hr
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: No biodegradation studies were located for acetylsalicylic acid in soil or natural water(SRC, 2008); however, acetylsalicylic acid was classified as readily biodegradable in screening tests using sewage sludge inoculum(1,2). Conversely, only a 0.09% total biodegradation was predicted in a study of a UK sewage treatment plant; the compound is detected in the UK environment(3).
12.3 Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for acetylsalicylic acid (SRC), using a log Kow of 1.19(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
The Koc of acetylsalicylic acid is estimated as 100(SRC), using a log Kow of 1.19(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that acetylsalicylic acid is expected to have high mobility in soil(SRC). The pKa of acetylsalicylic acid is estimated as 3.49(4), indicating that this compound will primarily exist as an anion in the environment and anions generally do not adsorb as strongly to soils containing organic carbon and clay than their neutral counterparts(5).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
| ADR/RID: Not dangerous goods. | IMDG: Not dangerous goods. | IATA: Not dangerous goods. |
14.2 UN Proper Shipping Name
| ADR/RID: unknown |
| IMDG: unknown |
| IATA: unknown |
14.3 Transport hazard class(es)
| ADR/RID: Not dangerous goods. | IMDG: Not dangerous goods. | IATA: Not dangerous goods. |
14.4 Packing group, if applicable
| ADR/RID: Not dangerous goods. | IMDG: Not dangerous goods. | IATA: Not dangerous goods. |
14.5 Environmental hazards
| ADR/RID: no | IMDG: no | IATA: no |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| acetylsalicylic acid | acetylsalicylic acid | 50-78-2 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
16.Other information
Information on revision
| Creation Date | Aug 11, 2017 |
|---|---|
| Revision Date | Aug 11, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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