3D Mol Similar

Meloxicam

: Iupac Name：4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ6,2-benzothiazine-3-carboxamide; CAS No.: 71125-38-7; Molecular Weight：351.40072; Modify Date.: 2023-02-09 14:23; Introduction:
Meloxicam, with the chemical formula C14H13N3O4S2 and CAS registry number 71125-38-7, is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to reduce pain, inflammation, and stiffness caused by conditions such as arthritis. It belongs to the class of drugs known as selective COX-2 inhibitors, which work by blocking the production of certain chemicals in the body that cause inflammation. Meloxicam is available in tablet form and is typically taken once daily. Common side effects may include stomach upset, dizziness, and headache. It is important to note that meloxicam should be used with caution in individuals with a history of heart disease or gastrointestinal bleeding. As with any medication, it is recommended to consult with a healthcare professional before starting meloxicam to ensure its appropriate use and to discuss any potential risks or concerns.
View more+

Request For Quotation

1. Names and Identifiers

: 1.1 Name; Meloxicam; 1.2 Synonyms; (3Z)-3-[hydroxy-[(5-methyl-2-thiazolyl)amino]methylidene]-2-methyl-1,1-dioxo-1λ6,2-benzothiazin-4-one 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-, 1,1-dioxide 2H-1,2-Benzothiazine-3-carboximidic acid, 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-, 1,1-dioxide 3-{Hydroxy[(5-methyl-1,3-thiazol-2-yl)amino]methylene}-2-methyl-2,3-dihydro-4H-1,2-benzothiazin-4-one 1,1-dioxide 3-{hydroxy[(5-methyl-1,3-thiazol-2-yl)amino]methylidene}-2-methyl-3,4-dihydro-2H-1λ6,2-benzothiazine-1,1,4-trione 4H-1,2-Benzothiazin-4-one, 2,3-dihydro-3-[hydroxy[(5-methyl-2-thiazolyl)amino]methylene]-2-methyl-, 1,1-dioxide 4-hydroxy-2-méthyl-N-(5-méthyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxyde 4-Hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazin-3-crboxamide 1,1-dioxide 4-Hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide 4-Hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboximidic acid 1,1-dioxide 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-1,1-dioxide-2H-1,2-benzothiazine-3-carboxamide 4-Hydroxy-2-Methyl-N-(5-Methylthiazol-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxaMide 1,1-dioxide Meloxciam Meloxicam (400 mg) MeloxicaM (Mobic) meloxicam (tautomer) MeloxicaM API MeloxicaM, BP MeloxicamUsp27 Metacam MFCD11046047 MFCD28656761 MOBEC MOBIC Mobicox Movalis Movatec Parocin structure was taken from Chemical Abstracts Index Guide, number; View all

1.3 CAS No.: 71125-38-7

1.4 CID: 54677470

1.5 EINECS(EC#): 615-253-8

1.6 Molecular Formula: C14H13N3O4S2 (isomer)

1.7 Inchi: InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)

1.8 InChIkey: ZRVUJXDFFKFLMG-UHFFFAOYSA-N

1.9 Canonical Smiles: CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O

1.10 Isomers Smiles: CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O

2. Properties

2.1 Density: 1.613

2.1 Melting point: 255 oC

2.1 Boiling point: 581.3±60.0

2.1 Refractive index: 1.72

2.1 Flash Point: 305.4±32.9 °C

2.1 Precise Quality: 351.03500

2.1 PSA: 136.22000

2.1 logP: 3.04260

2.1 Solubility: DMSO: soluble

2.2 Appearance: Light Yellow Solid

2.3 Storage: Keep Cold.

2.4 Chemical Properties: Light Yellow Solid

2.5 Color/Form: yellow

2.6 pKa: 4.08 in water; 4.24 ± 0.01 in water/ethanol (1:1); 4.63 ± 0.03 in water/ethanol (1:4)

2.7 Water Solubility: DMSO: soluble

2.8 Stability: Stable. Incompatible with strong oxidizing agents.

2.9 StorageTemp: 0-6°C

3. Use and Manufacturing

3.1 Definition: ChEBI: A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.

3.2 General Description: Meloxicam (Mobic) is a selective COX-2 inhibitor amongoxicams indicated for use in RA and OA. It also has a relativelylong half-life of 15 to 20 hours and has a much lowerrate of serious GI side effects and a lower than average riskof nephropathy when compared with other conventionalNSAIDs.196 The recommended dose is 7.5 mg once dailywith a maximum of 15 mg/d. Meloxicam is metabolized inhumans mainly by CYP2C9 (with a minor contribution viaCYP3A4) to 5'-hydroxymethylmeloxicam and 5 carboxymeloxicam.In large-scale comparative trials, meloxicam was foundto be at least as effective as most conventional NSAIDs inthe treatment of rheumatic disease or postoperative pain, buthas demonstrated a more favorable GI tolerability profile.

3.3 Usage: Preferential cyclooxygenase (COX-2) inhibitor. Sudoxicam and Meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) from the enol-carboxamide class.

4. Safety and Handling

4.1 Symbol: GHS06

4.1 Hazard Codes: Xn

4.1 Signal Word: Danger

4.1 Risk Statements: R22

4.1 Safety Statements: 26

4.1 Packing Group: III

4.1 Hazard Class: 6.1

4.1 Hazard Declaration: H301

4.1 RIDADR: UN 2811 6.1/PG 3

4.1 Caution Statement: P301 + P310

4.1 WGK Germany: 3

4.1 RTECS: DL0702000

4.1 Safety: Hazard Codes:Xn
Risk Statements:22-36/37/38
22:Harmful if swallowed
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
RIDADR:UN 2811 6.1/PG 3
WGK Germany:3

4.2 Specification: Light Yellow Solid
usageEng:Preferential cyclooxygenase (COX-2) inhibitor. Sudoxicam and Meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) from the enol-carboxamide class.
Safety Statements:26
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice

4.3 Toxicity: LD50 orally in mice: 470 mg/kg (Trummlitz, 1980)

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Reproductive toxicity, Category 1A

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H360 May damage fertility or the unborn child H412 Harmful to aquatic life with long lasting effects
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P280 Wear protective gloves/protective clothing/eye protection/face protection. P273 Avoid release to the environment.
Response	P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/\u2026 P321 Specific treatment (see ... on this label). P330 Rinse mouth. P308+P313 IF exposed or concerned: Get medical advice/ attention.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

View all

6. Synthesis Route

71125-38-7Total: 10 Synthesis Route

81-07-2 171 Suppliers

71125-38-7 409 Suppliers

Literatures:
Journal of Medicinal Chemistry, , vol. 40, # 6 p. 980 - 989
Yield: null

6639-62-9 6 Suppliers

71125-38-7 409 Suppliers

Literatures:
Journal of Medicinal Chemistry, , vol. 40, # 6 p. 980 - 989
Yield: null

35511-14-9 14 Suppliers

71125-38-7 409 Suppliers

Literatures:
Journal of Medicinal Chemistry, , vol. 40, # 6 p. 980 - 989
Yield: null

View all

7. Precursor and Product

precursor:

892395-40-3

244241-52-9

35511-14-9

95-50-1

81-07-2

6639-62-9

35511-15-0

24683-26-9

7305-71-7

24683-25-8

product :

71125-39-8

1145656-36-5

8. Other Information

8.0 Usage: Meloxicam is developed for the treatment of rheumatoid arthritis and osteoarthritis. It is currently for the treatment of osteoarthritis and rheumatoid arthritis.

9. Computational chemical data

Molecular Weight: 351.40072g/mol
Molecular Formula: C₁₄H₁₃N₃O₄S₂
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 351.03474825
Monoisotopic Mass: 351.03474825
Complexity: 628
Rotatable Bond Count: 2
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 7
Topological Polar Surface Area: 136
Heavy Atom Count: 23
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1
CACTVS Substructure Key Fingerprint: AAADccBzOABgAAAAAAAAAAAAAAAAAWAAAAAwQAAAAAAAAACBwAAAHgQQSAAADAzB2gQ/kZLIEgqsAjV3dHDC8LlxKDlJ2ByoSMiIZiLAGTCUcAAswQNImSeAwCAOAAAAAAAEAAAAAAAAAAgAAAAAAAAAAA==

10. Question & Answer

Is Meloxicam Safe for Long-Term Use? Jul 09 2024
Introduction Meloxicam is an oxicam derivative and a member of the enolic group of NSAIDs. While it shows some COX-2 selectivity, it is not classified as a selective COX-2 inhibitor by the US FDA. Ava..
Who should avoid using Meloxicam? Feb 20 2023
Meloxicam is a medication that provides antipyretic, analgesic, and anti-inflammatory effects. It is generally safe and effective for treating various diseases. However, it is important to be aware of..
Which is more effective: Celecoxib or Meloxicam? Feb 13 2023
Celecoxib and Meloxicam are both relatively new anti-inflammatory and analgesic drugs used primarily for the treatment of joint pain. They belong to the class of nonsteroidal anti-inflammatory drugs (..
What is the dosage and usage of Meloxicam? Nov 10 2022
Medically, Meloxicam is considered an anti-inflammatory drug that has excellent therapeutic effects on symptoms of rheumatoid arthritis and osteoarthritis. It is important to strictly follow the instr..

11. Recommended Suppliers

Global380SuppliersView all >>

Hebei Yanxi Chemical Co.,Ltd Diamond member

6YRS

Products:Division I, the main production Lead acetate phenylacetamide Cyromazine quality is very good!
Tel:86-185-31123677
Email:xing@yan-xi.com

Meloxicam

Purity:99%Packing: 200kg/bag FOB
Price: 1 USD/kilogram
Time: 2024/11/14

Inquire

Hebei Crovell Biotech Co. Ltd Diamond member

4YRS

Products:Cosmetic Raw Materials,solvents,etc.
Tel:86-311-66562153
Email:breeduan@crovellbio.com

Factory Supply meloxicam Cas 71125-38-7

Purity:99%Packing: 200kg/bag FOB
Price: 1 USD/kilogram
Time: 2024/11/15

Inquire

Hebei Saisier Technology Co., LTD Diamond member

2YRS

Products:Our company specializes in the research and development of fine chemicals, food additives and pharmaceutical raw materials
Tel:86-13032687-050
Email:lily@hbsaisier.cn

Meloxicam