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Lovastatin 75330-75-5

Lovastatin (CAS 75330-75-5, C24H36O5), is a white crystalline powder, widely used in the treatment of high cholesterol and prevention of cardiovascular diseases, with the ability to inhibit the enzyme HMG-CoA reductase, which is involved in cholesterol synthesis. Lovastatin plays a crucial role in the management of hyperlipidemia and reducing the risk of coronary heart disease.

Chemical Name Lovastatin
CAS Registry Number 75330-75-5
PubChemID 53232
Molecular Weight 404.547
PSA 72.83000
LogP 4.19550
EINECS 616-212-7
Molecular Formula C24H36O5
Synonyms
  • (+)-Mevinolin
  • (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl (S)-2-Methylbutyrate
  • (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate
  • (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
  • (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl-(2S)-2-methylbutanoat
  • (2S)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
  • [1S-[1a(R*),3a,7b,8b(2S*,4S*),8ab]]-2-Methylbutanoic Acid1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl Ester
  • 1,2,6,7,8,8a-Hexahydro-b,d-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid d-Lactone
  • 2b,6a-Dimethyl-8a-(2-methyl-1-oxobutoxy)mevinic Acid Lactone
  • 6a-Methylcompactin
  • Altocor
  • Altoprev
  • Antibiotic MB 530B
  • Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
  • MFCD00072164
  • msd803
  • Simvastatin Impurity 5
 

75330-75-5 Properties

  • Density 1.12
    Boiling Point 559.2 oC at 760 mmHg
    Flash Point 185.3 oC
    Melting Point 175℃
    Refractive Index 320 ° (C=0.5, CH3CN)
    HS Code 2932999099
 

75330-75-5 Safety Infomation

  • Safety Statements S22;S24/25
    Risk Statements R36/37/38
    Hazard Codes
    HazardClass 9
    Hazard Note H302
    PackingGroup III
    Transport 3077
 

75330-75-5   Synthesis Route

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Medication Guide
  • Effects of Medicaiton

    The purpose of Lovastatin

    Lovastatin is a medication used to lower cholesterol levels in the blood. It belongs to a class of drugs called statins. By reducing the production of cholesterol in the liver, Lovastatin helps to prevent the build-up of plaque in the arteries and reduces the risk of heart disease and stroke.
  • Mechanism of medication

    Lovastatin is prescribed in combination with diet, weight-loss, and exercise to lower the risk of heart attack and stroke, as well as to reduce the likelihood of requiring heart surgery in individuals with existing heart disease or those at risk of developing it. Additionally, Lovastatin is used to decrease the levels of cholesterol and other fatty substances in the blood. It belongs to a class of medications known as HMG CoA reductase inhibitors (statins). The drug works by slowing down the production of cholesterol in the body, thereby reducing the buildup of cholesterol on the arterial walls and improving blood flow to the heart, brain, and other parts of the body.

    Accumulation of cholesterol and fats on the arterial walls, a process called atherosclerosis, can lead to reduced blood flow and oxygen supply to the heart, brain, and other organs. By lowering cholesterol and fat levels in the blood, Lovastatin helps prevent heart disease, angina (chest pain), strokes, and heart attacks.
  • Special Dietary
    Eat a low-fat, low-cholesterol diet. It is important to follow all exercise and dietary recommendations provided by your doctor or dietitian. For additional dietary information, you can visit the National Cholesterol Education Program (NCEP) website at http://www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf.
    Avoid consuming grapefruit juice while taking lovastatin.
  • Special precautions

    Purpose of Lovastatin

    • Lovastatin is used to lower cholesterol levels in the blood and reduce the risk of heart disease.
    • It is prescribed to patients with high cholesterol levels who have not been able to lower their cholesterol through diet and exercise alone.
    • Lovastatin works by blocking the enzyme in the liver that is responsible for producing cholesterol, thereby reducing the amount of cholesterol in the blood.
    • It is important to follow a healthy diet and exercise regularly while taking lovastatin to achieve the best results.
    • Lovastatin is not a cure for high cholesterol, but it can help manage the condition and reduce the risk of heart-related complications.
  • Usage of Medication
    Lovastatin is a prescription medication that is available in tablet and extended-release tablet forms. The regular tablet is typically taken once or twice a day with meals, while the extended-release tablet is taken once a day at bedtime. It is important to take lovastatin at the same time(s) every day. Follow the instructions on your prescription label carefully and ask your doctor or pharmacist for clarification if needed. Take lovastatin exactly as directed by your doctor and do not take more or less of it or take it more frequently than prescribed.
    Swallow the extended-release tablets whole and do not split, chew, or crush them.
    Your doctor may start you on a low dose of lovastatin and gradually increase your dose, but no more than once every 4 weeks.
    Continue taking lovastatin even if you feel well and do not stop taking it without consulting your doctor.
  • Other usage

    This medication is prescribed for various uses. Please consult your doctor or pharmacist for more information.
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